cailynn
14 posts
May 17, 2026
11:59 PM
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A dCas9-VPH overexpressing cell line is a genetically engineered model that expresses dead Cas9 (dCas9) fused with the VPH transactivation domain, enabling precise gene activation without causing double-strand breaks. These cell lines are valuable tools for epigenetic regulation, gene function analysis, and transcriptional activation screening. By enabling targeted control of endogenous gene expression, they offer critical insights into gene networks and disease pathways.
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